Scaffolds

Bioresorbable scaffolds: everything resolved?

So, knowing the good results with DES the question is if there is still room and need for further improvement? After the introduction of the bioresorbable scaffold (BRS) and the promising results of the Absorb A and B trial, one would think that we are really missing the boat if we do not use this novel but still expensive device. The major advantage of the new scaffolds promises to overcome th...

ERK Signals: Scaffolding Scaffolds?

ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned, and also provide signal fidelity by isolating...

FRET-ing over scaffolds

pposites really do attract. Results on page 101 by Oliveria et al. show that, although they perform opposing functions, a kinase and a phosphatase linked to synaptic plasticity are close neighbors at the plasma membrane. The two are brought together by the scaffolding protein AKAP79 into a complex that may be important for efficient learning. The close proximity of the three proteins is uncover...

Biofabrication of Tissue Scaffolds

Microfabrication of PDLLA scaffolds.

This study aimed to comprehend the potentialities of the microfabrication to produce tissue-engineering scaffolds. Structures presenting homogeneously distributed pores of size 100 and 200 µm were fabricated through layer-by-layer deposition of filaments of poly(D,L-lactic acid) (PDLLA) prepared from dichloromethane/dimethylformamide solutions. Rheological tests on the solution and molecular we...